A distributed hydrological model is established for Dongjiang watershed based on Hydrological Simulation Program-Fortran (HSPF) Model. The theory of the construction, the data preparation, the model construction and model calibration are presented in details. The watershed is divided into 51 subfields from the perspective of spatial heterogeneity; while in terms of physical heterogeneity, the land use type, soil type and slope aspect are overlaid into 29 types of underlying surfaces. The relative errors at two calibrated stations (Heyuan station and Boluo station) are less than 15% and the NASH coefficients are larger than 0.9, which indicates a favorable simulation effect.