To study the characteristics of pile-soil interaction and the resistance of frame anti-slide piles, a 3-D finite element model of anti-slide frame-piles was established for Hongshibao landslide control works at Badong County in the Three Gorges Reservoir Area. Impacts on pile-soil interaction exerted by the physical and mechanical parameters of sliding body and sliding bed and the parameters of pile-soil interface were considered during the model establishment. The interaction of pile-beam-soil was investigated through observing the variation characteristics of internal force and displacement of the piles. Simulation results showed that the frame beam coordinated well with the displacement of front and back piles, and the displacement value of frame piles was consistent with that of soil among the piles. A spatial structure of large integral stiffness was thus formed by the piles and the soil among them. The results suggested that anti-slide frame-piles are of large stiffness and stability, and have equivalent support effect to that of multi-arch structure.