On the basis of fuzzy matter-element analysis and in combination with entropy weights, a matter-element model was established to evaluate groundwater quality. Regarding the water quality level as the object of matter-element, and constructing the compound fuzzy matter-element through various evaluation indexes and corresponding fuzzy values, the water quality evaluation was achieved through calculating Hamming approach degree between the fuzzy matter-element and the standard fuzzy matter-element. Adopting the entropy method to determine weights, the man-made effect may be avoided. The model was applied to evaluate the middle-deep level groundwater quality of Jiaozuo main city area. The results show that applying the model to evaluate groundwater quality is reasonable and feasible and the approach is simple and convenient to operate. The paper provides a new effective method for the comprehensive evaluation of water quality.