Since the construction of Danjiangkou Reservoir, the water and sediment transportation in the natural river course has been changed. The discharge and sediment into the Danjiangkou Reservoir was controlled by the reservoir operation, so the river bed was reformed within the reservoir area. From the completion of Danjiangkou Reservoir to 2003, more than 98% sediment load into the reservoir deposited, of which 85% was distributed in the reservoir area, wash load was released by reservoir. On the basis of the history and recent data of Danjiangkou Reservoir, the sediment distribution in three dimension of the Han River main stream reservoir area was analyzed in detail, this result may provide a better reference for Three Gorges Reservoir operation.