By making use of strong capability in computing of Matlab and features of friendly interface of VB, the visual neural network by using ActiveX technology is realized and used to analyze in-situ stress field in this paper. On the basis of the calculated results of multivariate linear regression analysis, the uniform design method is carried out to settle parameters with different combinations of factor levels. Training samples are gained by FEM analysis. The rock mass is in elastic state when the linear regression method is carried out, and with the ANN method, the training samples are difficult to generate. Combining the linear regression method with ANN method can solve these problems perfectly. Infact, one needs to know the status of the in-situ stress field at some important location in the engineering. By using neural network method, intelligent expression method of the in-situ stress field is presented in this paper. The developed man-computer interface has the property of easy use in the actual engineering.