On the basis of the simulation technique of 3D finite element steady and un-steady seepage, this paper has finished the calculation analysis on south bank channel high slope seepage status of Yellow River Tunnel Project in first-stage of Middle Route South-to-North Water Transfer Project. According to seepage control measures proposed to be employed, the seepage condition of channel slope has been calculated using different drainage measures, during periods of construction, completion, operation and overhaul of the slope respectively, and the drainage effects of various seepage control measures have been analyzed, so, the important result has been achieved for seepage control design of channel slope at different phases.