[Objective] Sedimentation at the downstream of sluice gates severely constraints the drainage capacity of pumping sluices in the tidal reaches of the Yangtze River，and also raises dredging costs. This study seeks to elucidate the causes and find solutions for the sedimentation of pumping sluices by optimizing their layouts to improve regional drainage capacity and river hydrodynamic condition. [Methods] The Beiheng River Pumping Station and Sluice Project in Pudong New Area，Shanghai was taken as a case study. Numerical simulations and analyses of the engineering effects under different layout schemes were conducted using measured data analysis and a three-dimensional hydrodynamic-sediment mathematical model. By comprehensively comparing the flow patterns，velocity distributions，and erosion-deposition results of each layout scheme，the planar layout of the Beiheng River project was evaluated. [Results and Conclusion] （1） Different planar layouts of pumping station and sluice projects in the tidal reaches of the Yangtze River result in significant differences in hydrodynamic characteristics and sedimentation control effectiveness. （2） The length of the straight flow section upstream of the sluice and the coverage area of the high-velocity zone downstream of the sluice are the core factors controlling sedimentation downstream of the sluice. （3） By adapting the planar layout of the pumping station and sluice to local topography and boundary conditions，hydrodynamic-sediment simulations can provide universal design guidelines for the construction and renovation of similar river-connected pumping stations and sluices in the Yangtze River Delta region. This is of great significance for enhancing the flood control resilience of coastal urban clusters and advancing the modernization of water management systems.