Hydraulic fracturing easily occurs in rock masses under high-pressure packer tests, involving dual water conduction via pores and cracks. This interaction between the seepage and stress fields results in spatial-temporal variations in rock mass permeability parameters. For accurate permeability parameter inversion during high-pressure packer tests, it is recommended to consider the change in permeability coefficient before and after fracture occurrence under hydro-mechanical coupling of dual media. A hydro-mechanical coupling numerical model is employed to simulate high-pressure packer tests, and parameter inversion is conducted using on-site test data to calculate limestone permeability across different pressure stages. Key findings include: before hydraulic fracturing, as injection pressure increases, permeability and pore water pressure sees distinct boundaries among different pressure stages, with inverted permeability closely aligning with specified formula values. After hydraulic fracturing, rock mass permeability increases by about 2 times, accompanied by sharp declines in matrix pore medium permeability and flow rates.