In recent years, the most stringent water resource management system has played an increasingly significant role in promoting water resource management. Water consumption per 10,000 yuan of industrial added value, which reflects the efficiency of industrial water use, is an important indicator of the control red line for water use efficiency. Studying the impact of the most stringent water resources management system on the water consumption per 10 000 yuan of industrial added value is of great significance to promoting the implementation of the most stringent water resources management system and supporting water resources management. With Zhejiang Province as a typical case, the change rule of water consumption per 10 000 yuan of industrial added value from 2005 to 2017 is analyzed via the MK-P test method. An indicator evaluation system is established, and the importance of each indicator is depicted quantitatively using improved analytical hierarchy process (AHP). According to the actual situation of the case, the evaluation model was evaluated by multi-objective decision-making. Results show that, after the implementation of the most stringent water resource management system, the index have dropped significantly. The evaluation system is reasonable, and the influence weight of relevant work reached 71%. The most stringent water resource management system has significant influence on improving the industrial water use efficiency.