Although protection have been carried out over the years, bank collapse still occurs frequently at Nanwuzhou river reach. Underwater riprap needs tremendous stone extraction, causing irreversible damage to the ecological environment. Meanwhile, slope cut in large areas is needed in the project region to maintain the slope stability. At some segments, dike retreatment, farmland occupation, hydraulic structure rebuilding, irrigation and drainage facilities rebuilding are required, hence the economic and social benefits need to be comprehensively assessed. In view of this, main influencing factors affecting the bank collapse, and offshore topographic change are analyzed. New measures to solve these problems are proposed as follows: toe protection by rockfill of the underwater bearing platform, toe protection by anti-slide pile with sand filled bag, together with three-dimensional vegetation slope protection as the second level slope protection work above water. Taking these new measures will not change the river regime, the stability of the opposite bank, nor the flood protection situations or the existing navigation channel.